Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial
권민정, 최용훈, 김근서, 장나희, 김영균, 이효정,
소속 상세정보
권민정 ( Kwoen Min-Jeong ) - Seoul National University Bundang Hospital Section of Dentistry Department of Oral and Periodontology
최용훈 ( Choi Yong-Hoon ) - Seoul National University Bundang Hospital Section of Dentistry Department of Conservative Dentistry
김근서 ( Kim Keun-Suh ) - Seoul National University Bundang Hospital Section of Dentistry Department of Oral and Periodontology
장나희 ( Chang Na-Hee ) - Seoul National University Bundang Hospital Biomedical Research Institute
김영균 ( Kim Young-Kyun ) - Seoul National University Bundang Hospital Section of Dentistry Department of Oral and Maxillofacial Surgery
이효정 ( Lee Hyo-Jung ) - Seoul National University Bundang Hospital Section of Dentistry Department of Oral and Periodontology
Abstract
Objectives: Hyaluronoglucosaminidase (hyaluronidase) increases the local intercellular permeability of the peripheral lymphatic channel and capillaries, which may help reduce edema. In the present study, the effects of hyaluronidase on postoperative edema and pain reduction were evaluated.
Materials and Methods: The study included 38 patients who underwent guided bone regeneration (GBR) surgery before implantation. Patients were randomly assigned to either the control group (n=20) or the test group (n=18). Hyaluronidase was injected into the GBR site of subjects in the test group. Postoperative edema was evaluated by measuring the distance between specific facial landmarks immediately after surgery (T1) and 2-4 days after surgery (T2). The degree of pain at T2 and at 10-14 days after surgery (T3) was assessed.
Results: In the test group, the degree of swelling was lower than in the control group, however, only two measurements, from the tragus to the mouth corner and from the outer canthus to the mouth corner, showed statistically significant differences (P=0.012 and P=0.001, respectively). The anti-edema effect of hyaluronidase was more effective in the maxilla than in the mandible. In the maxilla, the percentage of facial swelling was significant for three measurements. However, in the mandible, the percentage of facial swelling was significant for only one measurement. Low levels of pain that were similar at T2 and T3 were reported in both groups.
Conclusion: The results indicate the degree of swelling was lower in the test group and hyaluronidase appeared to be more effective in the maxilla. The degree of pain reduction was similar between groups. Further in vivo and randomized controlled trials with larger sample sizes are warranted.
키워드
Hyaluronoglucosaminidase; Bone graft; Guided bone regeneration; Postoperative edema; Pain reduction
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